NUDT15 Antibody

Size

100ug

Clone Number

Aliases

8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody; 8-oxo-dGTPase NUDT15 antibody; A730068G11Rik antibody; EC 3.1.6.- antibody; FLJ10956 antibody; MGC104352 antibody; MTH2 antibody; MutT homolog 2 antibody; Nucleoside diphosphate-linked moiety X motif 15 antibody; NUD15_HUMAN antibody; Nudix (nucleoside diphosphate linked moiety X)-type motif antibody; Nudix motif 15 antibody; NUDT15 antibody; OTTHUMP00000018389 antibody; Probable 7 antibody; Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody; RP11-90M2.1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NV35

Immunogen

Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 protein (1-164AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NUDT15

Research Areas

Epigenetics and Nuclear Signaling