NUDT1 Antibody

Size

100ug

Clone Number

Aliases

2-hydroxy-dATP diphosphatase antibody; 7 8 dihydro 8 oxoguanine triphosphatase antibody; 7 antibody; 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody; 8 oxo 7 8 dihydroguanosine triphosphatase antibody; 8 oxo dGTPase antibody; 8-dihydro-8-oxoguanine triphosphatase antibody; 8-oxo-dGTPase antibody; 8ODP_HUMAN antibody; MTH 1 antibody; MTH1 antibody; MutT human homolog 1 antibody; Nucleoside diphosphate linked moiety X motif 1 antibody; Nucleoside diphosphate linked moiety X type motif 1 antibody; Nucleoside diphosphate-linked moiety X motif 1 antibody; Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody; Nudix hydrolase 1 antibody; Nudix motif 1 antibody; Nudix type motif 1 antibody; NUDT 1 antibody; Nudt1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P36639

Immunogen

Recombinant Human 7,8-dihydro-8-oxoguanine triphosphatase protein (49-82AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NUDT1

Research Areas

Epigenetics and Nuclear Signaling