NTAN1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

NTAN1 antibody; Protein N-terminal asparagine amidohydrolase antibody; EC 3.5.1.121 antibody; Protein NH2-terminal asparagine amidohydrolase antibody; PNAA antibody; Protein NH2-terminal asparagine deamidase antibody; PNAD antibody; Protein N-terminal Asn amidase antibody; Protein N-terminal asparagine amidase antibody; Protein NTN-amidase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96AB6

Immunogen

Recombinant Human Protein N-terminal asparagine amidohydrolase protein (219-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NTAN1

Research Areas

Cell biology