NSJ Bioreagents
SKU:V9768-100UG
Recombinant Desmin Antibody, 100 ug
Recombinant Desmin Antibody, 100 ug
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Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Specifications
| Catalog No | V9768-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | rDES/1711 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human, Mouse, Rat |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Application Note | Optimal dilution of the recombinant Desmin antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | Recombinant human protein was used as the immunogen for the recombinant Desmin antibody. |
| Purity | Protein G affinity chromatography |
| Storage | Store the recombinant Desmin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). |
| Limitation | This recombinant Desmin antibody is available for research use only. |
| Uniprot # | P17661 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-desmin-antibody-rdes1711-v9768 |
| Title | Recombinant Desmin Antibody |
| Description | Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. |
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