NSJ Bioreagents
SKU:V9749-20UG
QKI Antibody / Protein Quaking, 20 ug
QKI Antibody / Protein Quaking, 20 ug
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QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.
Specifications
| Catalog No | V9749-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-QKI-2F10 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c |
| Species Reactivity | Human |
| Application | ELISA, FACS, IF, WB |
| Application Details | ELISA (concentration assay dependent,Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml |
| Application Note | Optimal dilution of the QKI antibody should be determined by the researcher. |
| Localization | Nucleus, Cytoplasm |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the QKI antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the QKI antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This QKI antibody is available for research use only. |
| Uniprot # | Q96PU8 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/qki-antibody-protein-quaking-pcrp-qki-2f10-v9749 |
| Title | QKI Antibody / Protein Quaking |
| Description | QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events. |
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