NSJ Bioreagents
SKU:V9739-100UG
MED22 Antibody, 100 ug
MED22 Antibody, 100 ug
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Med22 is a subunit of the RNA polymerase II (Pol II) transcriptional mediator complex. The mediator complex is a coactivator involved in the regulated transcription of Pol II-dependent genes. Functioning as a bridge to convey information from gene-specific regulatory proteins to the basal Pol II transcription machinery, the mediator complex is recruited to promoter regions by directly interacting with regulatory proteins. The mediator complex also serves as a scaffold for the assembly of a functional pre-initiation complex with Pol II and other general transcription factors. Med22 (mediator complex subunit 22), also known as SURF5 (surfeit locus protein 5), is a ubiquitously expressed 200 amino acid nuclear protein that is one of several components of the mediator complex. There are two isoforms of Med22 that are produced as a result of alternative splicing events.
Specifications
| Catalog No | V9739-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-MED22-2A7 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Species Reactivity | Human |
| Application | ELISA, IF, FACS |
| Application Details | ELISA (order BSA-free format for coating),Immunofluorescence: 0.5-2ug/ml,Flow cytometry: 0.5-2ug/million cells |
| Application Note | Optimal dilution of the MED22 antibody should be determined by the researcher. |
| Localization | Nucleus |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the MED22 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the MED22 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This MED22 antibody is available for research use only. |
| Uniprot # | Q15528 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/med22-antibody-pcrp-med22-2a7-v9739 |
| Title | MED22 Antibody |
| Description | Med22 is a subunit of the RNA polymerase II (Pol II) transcriptional mediator complex. The mediator complex is a coactivator involved in the regulated transcription of Pol II-dependent genes. Functioning as a bridge to convey information from gene-specific regulatory proteins to the basal Pol II transcription machinery, the mediator complex is recruited to promoter regions by directly interacting with regulatory proteins. The mediator complex also serves as a scaffold for the assembly of a functional pre-initiation complex with Pol II and other general transcription factors. Med22 (mediator complex subunit 22), also known as SURF5 (surfeit locus protein 5), is a ubiquitously expressed 200 amino acid nuclear protein that is one of several components of the mediator complex. There are two isoforms of Med22 that are produced as a result of alternative splicing events. |
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