NSJ Bioreagents
SKU:V9714-100UG
B-cell lymphoma/leukemia 11A Antibody / BCL11A, 100 ug
B-cell lymphoma/leukemia 11A Antibody / BCL11A, 100 ug
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Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
Specifications
| Catalog No | V9714-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-BCL11A-1H3 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1 |
| Species Reactivity | Human |
| Application | ELISA, FACS, IF |
| Application Details | ELISA (order BSA-free format for coating),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml |
| Application Note | Optimal dilution of the B-cell lymphoma/leukemia 11A antibody should be determined by the researcher. |
| Localization | Cytoplasm, Nucleus |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the B-cell lymphoma/leukemia 11A antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the B-cell lymphoma/leukemia 11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This B-cell lymphoma/leukemia 11A antibody is available for research use only. |
| Uniprot # | Q9H165 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/b-cell-lymphomaleukemia-11a-antibody-bcl11a-pcrp-bcl11a-1h3-v9714 |
| Title | B-cell lymphoma/leukemia 11A Antibody / BCL11A |
| Description | Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6. |
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