NSJ Bioreagents
SKU:V9687-20UG
Recombinant NPM1 Antibody / Nucleophosmin, 20 ug
Recombinant NPM1 Antibody / Nucleophosmin, 20 ug
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Recognizes a 33kDa glycoprotein identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.
Specifications
| Catalog No | V9687-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | NPM1/7072R |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant NPM1 antibody should be determined by the researcher. |
| Localization | Nucleus, Cytoplasm |
| Immunogen | A recombinant protein fragment was used as the immunogen for the recombinant NPM1 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant NPM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant NPM1 antibody is available for research use only. |
| Uniprot # | P06748 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-npm1-antibody-nucleophosmin-npm17072r-v9687 |
| Title | Recombinant NPM1 Antibody / Nucleophosmin |
| Description | Recognizes a 33kDa glycoprotein identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia. |
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