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NSJ Bioreagents
SKU:V9675-100UG
Recombinant MDM2 Antibody, 100 ug
Recombinant MDM2 Antibody, 100 ug
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$559.00 USD
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MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
Specifications
| Catalog No | V9675-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | MDM2/7061R |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | ELISA |
| Application Details | ELISA (order BSA-free format for coating) |
| Application Note | Optimal dilution of the recombinant MDM2 antibody should be determined by the researcher. |
| Localization | Nuclear |
| Immunogen | A portion of amino acids 126-254 was used as the immunogen for the recombinant MDM2 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant MDM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant MDM2 antibody is available for research use only. |
| Uniprot # | Q00987 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-mdm2-antibody-mdm27061r-v9675 |
| Title | Recombinant MDM2 Antibody |
| Description | MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers. |
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