NSJ Bioreagents
SKU:V9662-20UG
MIF Antibody / Macrophage Migration Inhibitory Factor, 20 ug
MIF Antibody / Macrophage Migration Inhibitory Factor, 20 ug
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Macrophage migration inhibitory factor, known as MIF or glycosylation-inhibiting factor (GIF), is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.
Specifications
| Catalog No | V9662-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | MIF/3489 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Species Reactivity | Human |
| Application | WB, IHC-P |
| Application Details | Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the MIF antibody should be determined by the researcher. |
| Localization | Secreted, Cytoplasm |
| Immunogen | A recombinant fragment from the human protein was used as the immunogen for the MIF antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the MIF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This MIF antibody is available for research use only. |
| Uniprot # | P14174 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/mif-antibody-macrophage-migration-inhibitory-factor-mif3489-v9662 |
| Title | MIF Antibody / Macrophage Migration Inhibitory Factor |
| Description | Macrophage migration inhibitory factor, known as MIF or glycosylation-inhibiting factor (GIF), is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases. |
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