NSJ Bioreagents
SKU:V9658-100UG
CK14 Antibody / Cytokeratin 14 / KRT14, 100 ug
CK14 Antibody / Cytokeratin 14 / KRT14, 100 ug
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Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells.Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors.Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.
Specifications
| Catalog No | V9658-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | KRT14/4130 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the CK14 antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | A portion of amino acids351-472 was used as the immunogen for the CK14 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the CK14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CK14 antibody is available for research use only. |
| Uniprot # | P02533 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/ck14-antibody-cytokeratin-14-krt14-krt144130-v9658 |
| Title | CK14 Antibody / Cytokeratin 14 / KRT14 |
| Description | Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells.Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors.Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast. |
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