NSJ Bioreagents
SKU:V9648-100UG
CNOT10 Antibody / CCR4-NOT transcription complex subunit 10, 100 ug
CNOT10 Antibody / CCR4-NOT transcription complex subunit 10, 100 ug
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CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.
Specifications
| Catalog No | V9648-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-CNOT10-1D5 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c |
| Species Reactivity | Human |
| Application | ELISA, FACS, IF, WB |
| Application Details | ELISA (order BSA-free format for coating),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml |
| Application Note | Optimal dilution of the CNOT10 antibody should be determined by the researcher. |
| Localization | Cytoplasm (Mitochondrion) and Nucleus (PML body) |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the CNOT10 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the CNOT10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CNOT10 antibody is available for research use only. |
| Uniprot # | Q9H9A5 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cnot10-antibody-ccr4-not-transcription-complex-subunit-10-pcrp-cnot10-1d5-v9648 |
| Title | CNOT10 Antibody / CCR4-NOT transcription complex subunit 10 |
| Description | CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. |
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