NSJ Bioreagents
SKU:V9646-100UG
SIRT3 Antibody, 100 ug
SIRT3 Antibody, 100 ug
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Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys2-His2-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
Specifications
| Catalog No | V9646-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-SIRT3-1C10 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a |
| Species Reactivity | Human |
| Application | ELISA, FACS, IF, WB |
| Application Details | ELISA (order BSA-free format for coating),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml |
| Application Note | Optimal dilution of the SIRT3 antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | Recombinant full-length human SIRT3 protein was used as the immunogen for the SIRT3 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the SIRT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This SIRT3 antibody is available for research use only. |
| Uniprot # | Q9NTG7 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/sirt3-antibody-pcrp-sirt3-1c10-v9646 |
| Title | SIRT3 Antibody |
| Description | Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys2-His2-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC). |
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