NSJ Bioreagents
SKU:V9637-20UG
Calcitonin Antibody / CALCA / CGRP, 20 ug
Calcitonin Antibody / CALCA / CGRP, 20 ug
Couldn't load pickup availability
Calcitonin is a hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or -CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.
Specifications
| Catalog No | V9637-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | CALCA/3310 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 2-4ug/ml |
| Application Note | Optimal dilution of the Calcitonin antibody should be determined by the researcher. |
| Localization | Cytoplasm, Secreted |
| Immunogen | A portion of amino acids 3-116 was used as the immunogen for the Calcitonin antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the Calcitonin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Calcitonin antibody is available for research use only. |
| Uniprot # | P01258 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/calcitonin-antibody-calca-cgrp-calca3310-v9637 |
| Title | Calcitonin Antibody / CALCA / CGRP |
| Description | Calcitonin is a hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or -CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species. |
Share
