NSJ Bioreagents
SKU:V9633-100UG
IL-25 Antibody / IL-17E, 100 ug
IL-25 Antibody / IL-17E, 100 ug
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Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV-13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length that is highly expressed in spleen and kidney.
Specifications
| Catalog No | V9633-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | IL25/625 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the IL-25 antibody should be determined by the researcher. |
| Localization | Secreted |
| Immunogen | A recombinant protein fragment was used as the immunogen for the IL-25 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the IL-25 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This IL-25 antibody is available for research use only. |
| Uniprot # | Q9H293 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/il-25-antibody-il-17e-il25625-v9633 |
| Title | IL-25 Antibody / IL-17E |
| Description | Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV-13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length that is highly expressed in spleen and kidney. |
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