NSJ Bioreagents
SKU:V9622-100UG
Glutamine Synthetase Antibody / GLUL, 100 ug
Glutamine Synthetase Antibody / GLUL, 100 ug
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Glutamine synthetase (GlSyn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
Specifications
| Catalog No | V9622-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | GLUL/6599 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Species Reactivity | Human |
| Application | WB, IHC-P |
| Application Details | Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the GLUL antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | A portion of amino acids 50-250 was used as the immunogen for the GLUL antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This GLUL antibody is available for research use only. |
| Uniprot # | P15104 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/glutamine-synthetase-antibody-glul-glul6599-v9622 |
| Title | Glutamine Synthetase Antibody / GLUL |
| Description | Glutamine synthetase (GlSyn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation. |
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