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NSJ Bioreagents
SKU:V9605-100UG
ECD Antibody / SGT1, 100 ug
ECD Antibody / SGT1, 100 ug
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Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
Specifications
| Catalog No | V9605-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | PCRP-ECD-1D10 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Species Reactivity | Human |
| Application | FACS, IF |
| Application Details | Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml |
| Application Note | Optimal dilution of the ECD antibody should be determined by the researcher. |
| Localization | Nucleus, Cytoplasm |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the ECD antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the ECD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ECD antibody is available for research use only. |
| Uniprot # | O95905 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/ecd-antibody-sgt1-pcrp-ecd-1d10-v9605 |
| Title | ECD Antibody / SGT1 |
| Description | Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. |
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