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NSJ Bioreagents
SKU:V9593-100UG
IL1 beta Antibody / IL1B, 100 ug
IL1 beta Antibody / IL1B, 100 ug
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$559.00 USD
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The IL1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Specifications
| Catalog No | V9593-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | IL1B/3993 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Species Reactivity | Human |
| Application | ELISA, IHC-P |
| Application Details | ELISA (order BSA-free format for coating),Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the IL1B antibody should be determined by the researcher. |
| Localization | Cytoplasm, Extracellular (secreted) |
| Immunogen | A recombinant protein fragment was used as the immunogen for the IL1B antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the IL1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This IL1B antibody is available for research use only. |
| Uniprot # | P01584 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/il1-beta-antibody-il1b-il1b3993-v9593 |
| Title | IL1 beta Antibody / IL1B |
| Description | The IL1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
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