NSJ Bioreagents
SKU:V9592-100UG
Osteopontin Antibody / OPN / SPP1, 100 ug
Osteopontin Antibody / OPN / SPP1, 100 ug
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Osteopontin is a bone matrix protein and a cytokine secreted by activated T cells. Osteopontin (OPN, also designated bone sialoprotein 1, urinary stone protein, spp-1, -1, nephropontin, uropontin) is an extracellular matrix cell adhesion phosphoglycoprotein. OPN is deposited into unmineralized matrix prior to calcification leading to localization at various tissue interfaces including cement lines, lamina limitans, and between collagen fibrils of fully matured hard tissues. While OPN is a major product of osteoblasts, it is also synthesized by brain and kidney cells. OPNs isolated from or secreted by various tissues have molecular weights due to post-translational modifications. OPN functions as a substrate for transglutaminase and is involved in cell adhesion, chemoattraction and immunomodulation.
Specifications
| Catalog No | V9592-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | OSP/4589 |
| Host Animal | Rat |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG1 |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the Osteopontin antibody should be determined by the researcher. |
| Localization | Secreted |
| Immunogen | Recombinant full-length rat Spp1/Osteopontin protein was used as the immunogen for the Osteopontin antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the Osteopontin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Osteopontin antibody is available for research use only. |
| Uniprot # | P10451 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/osteopontin-antibody-opn-spp1-osp4589-v9592 |
| Title | Osteopontin Antibody / OPN / SPP1 |
| Description | Osteopontin is a bone matrix protein and a cytokine secreted by activated T cells. Osteopontin (OPN, also designated bone sialoprotein 1, urinary stone protein, spp-1, -1, nephropontin, uropontin) is an extracellular matrix cell adhesion phosphoglycoprotein. OPN is deposited into unmineralized matrix prior to calcification leading to localization at various tissue interfaces including cement lines, lamina limitans, and between collagen fibrils of fully matured hard tissues. While OPN is a major product of osteoblasts, it is also synthesized by brain and kidney cells. OPNs isolated from or secreted by various tissues have molecular weights due to post-translational modifications. OPN functions as a substrate for transglutaminase and is involved in cell adhesion, chemoattraction and immunomodulation. |
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