NSJ Bioreagents
SKU:V9581-100UG
SMARCB1 Antibody / Integrase interactor 1 / INI1 / BAF47, 100 ug
SMARCB1 Antibody / Integrase interactor 1 / INI1 / BAF47, 100 ug
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The SMARCB1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
Specifications
| Catalog No | V9581-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | rSMARCB1/4588 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the SMARCB1 antibody should be determined by the researcher. |
| Localization | Nucleus |
| Immunogen | A portion of amino acids 257-359 was used as the immunogen for the SMARCB1 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the SMARCB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This SMARCB1 antibody is available for research use only. |
| Uniprot # | Q12824 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/smarcb1-antibody-integrase-interactor-1-ini1-baf47-rsmarcb14588-v9581 |
| Title | SMARCB1 Antibody / Integrase interactor 1 / INI1 / BAF47 |
| Description | The SMARCB1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues. |
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