NSJ Bioreagents
SKU:V9529SAF-100UG
Recombinant CFTR Antibody / Cystic Fibrosis Transmembrane Regulator, 100 ug
Recombinant CFTR Antibody / Cystic Fibrosis Transmembrane Regulator, 100 ug
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Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Specifications
| Catalog No | V9529SAF-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Format | Purified |
| Clone | rCFTR/7175 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant CFTR antibody should be determined by the researcher. |
| Localization | Cell surface, Cytoplasm |
| Immunogen | A portion of amino acids 550-850 was used as the immunogen for the recombinant CFTR antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant CFTR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant CFTR antibody is available for research use only. |
| Uniprot # | P13569 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-cftr-antibody-cystic-fibrosis-transmembrane-regulator-rcftr7175-v9529 |
| Title | Recombinant CFTR Antibody / Cystic Fibrosis Transmembrane Regulator |
| Description | Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. |
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