NSJ Bioreagents
SKU:V9497-100UG
Fibroblast Activation Protein Alpha Antibody / FAP, 100 ug
Fibroblast Activation Protein Alpha Antibody / FAP, 100 ug
Couldn't load pickup availability
FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.
Specifications
| Catalog No | V9497-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | FAP/4853 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the Fibroblast Activation Protein Alpha antibody should be determined by the researcher. |
| Localization | Cell surface, Cell membrane |
| Immunogen | A portion of amino acids 1-200 was used as the immunogen for the Fibroblast Activation Protein Alpha antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the Fibroblast Activation Protein Alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Fibroblast Activation Protein Alpha antibody is available for research use only. |
| Uniprot # | Q12884 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/fibroblast-activation-protein-alpha-antibody-fap-fap4853-v9497 |
| Title | Fibroblast Activation Protein Alpha Antibody / FAP |
| Description | FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility. |
Share
