NSJ Bioreagents
SKU:V9483-100UG
Alpha-1-Antichymotrypsin Antibody / AACT / SERPINA3, 100 ug
Alpha-1-Antichymotrypsin Antibody / AACT / SERPINA3, 100 ug
Couldn't load pickup availability
It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Specifications
| Catalog No | V9483-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | SERPINA3/4187 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the Alpha-1-Antichymotrypsin antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | A portion of amino acids A portion of amino acids 49-187 was used as the immunogen for the Alpha-1-Antichymotrypsin antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the Alpha-1-Antichymotrypsin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Alpha-1-Antichymotrypsin antibody is available for research use only. |
| Uniprot # | P01011 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/alpha-1-antichymotrypsin-antibody-aact-serpina3-serpina34187-v9483 |
| Title | Alpha-1-Antichymotrypsin Antibody / AACT / SERPINA3 |
| Description | It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity. |
Share
