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NSJ Bioreagents
SKU:V9451-20UG
Recombinant DNA topoisomerase I Antibody / TOP1MT, 20 ug
Recombinant DNA topoisomerase I Antibody / TOP1MT, 20 ug
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DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Specifications
| Catalog No | V9451-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | rTOP1MT/488 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant DNA topoisomerase I antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | Recombinant full-length human TOP1MT protein was used as the immunogen for the recombinant DNA topoisomerase I antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant DNA topoisomerase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant DNA topoisomerase I antibody is available for research use only. |
| Uniprot # | Q969P6 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-dna-topoisomerase-i-antibody-top1mt-rtop1mt488-v9451 |
| Title | Recombinant DNA topoisomerase I Antibody / TOP1MT |
| Description | DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity. |
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