NSJ Bioreagents
SKU:V9437-100UG
Recombinant CD30 Antibody, 100 ug
Recombinant CD30 Antibody, 100 ug
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Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located somewhere between aa 580-595 (cytoplasmic). CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Specifications
| Catalog No | V9437-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | rKi-1/6913 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant CD30 antibody should be determined by the researcher. |
| Localization | Cell Surface |
| Immunogen | A portion of amino acids 495-595 was used as the immunogen for the recombinant CD30 antibody. |
| Purity | Protein A affinity |
| Storage | Aliquot the recombinant CD30 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant CD30 antibody is available for research use only. |
| Uniprot # | P28908 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-cd30-antibody-rki-16913-v9437 |
| Title | Recombinant CD30 Antibody |
| Description | Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located somewhere between aa 580-595 (cytoplasmic). CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45). |
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