NSJ Bioreagents
SKU:V9421-100UG
Recombinant ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin, 100 ug
Recombinant ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin, 100 ug
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Specifications
| Catalog No | V9421-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | ACTN2/7039R |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant ACTN2 antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 557-692 from the human protein was used as the immunogen for the recombinant ACTN2 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant ACTN2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant ACTN2 antibody is available for research use only. |
| Uniprot # | P35609 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-actn2-antibody-alpha-actinin-2-sarcomeric-alpha-actinin-actn27039r-v9421 |
| Title | Recombinant ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin |
| Description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. |
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