NSJ Bioreagents
SKU:V9393SAF-100UG
Recombinant ESR1 Antibody / Estrogen Receptor alpha, 100 ug
Recombinant ESR1 Antibody / Estrogen Receptor alpha, 100 ug
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Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas.
Specifications
| Catalog No | V9393SAF-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Format | Purified |
| Clone | ESR1/6983R |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Species Reactivity | Human |
| Application | WB, IHC-P |
| Application Details | Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant ESR1 antibody should be determined by the researcher. |
| Localization | Nucleus |
| Immunogen | A portion of amino acids 495-595 was used as the immunogen for the recombinant ESR1 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant ESR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant ESR1 antibody is available for research use only. |
| Uniprot # | P03372 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-esr1-antibody-estrogen-receptor-alpha-esr16983r-v9393 |
| Title | Recombinant ESR1 Antibody / Estrogen Receptor alpha |
| Description | Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems.Studies have shown ER can be used as a tumor marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas. |
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