NSJ Bioreagents
SKU:V9389SAF-100UG
Recombinant FLG Antibody / Filaggrin, 100 ug
Recombinant FLG Antibody / Filaggrin, 100 ug
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Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Specifications
| Catalog No | V9389SAF-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Format | Purified |
| Clone | rFLG/1945 |
| Host Animal | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant FLG antibody should be determined by the researcher. |
| Localization | Cytoplasm |
| Immunogen | A portion of amino acids 198-288 was used as the immunogen for the recombinant FLG antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant FLG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant FLG antibody is available for research use only. |
| Uniprot # | P20930 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-flg-antibody-filaggrin-rflg1945-v9389 |
| Title | Recombinant FLG Antibody / Filaggrin |
| Description | Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. |
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