NSJ Bioreagents
SKU:V9295SAF-100UG
Recombinant CD7 Antibody, 100 ug
Recombinant CD7 Antibody, 100 ug
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Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Specifications
| Catalog No | V9295SAF-100UG |
|---|---|
| Family | Primary antibody |
| Qty | 100 ug |
| Formulation | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Format | Purified |
| Clone | CD7/6388R |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | IHC-P |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application Note | Optimal dilution of the recombinant CD7 antibody should be determined by the researcher. |
| Localization | Cell Surface |
| Immunogen | A portion of amino acids 72-175 was used as the immunogen for the recombinant CD7 antibody. |
| Purity | Protein A/G affinity |
| Storage | Aliquot the recombinant CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This recombinant CD7 antibody is available for research use only. |
| Uniprot # | P09564 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/recombinant-cd7-antibody-cd76388r-v9295 |
| Title | Recombinant CD7 Antibody |
| Description | Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. |
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