NANOG Antibody / Homeobox protein NANOG, 100ug

NANOG Transcription Factor antibody, also known as Nanog antibody, recognizes Nanog homeobox, a nuclear transcription factor encoded by the NANOG gene that plays a central role in pluripotency regulation and cellular plasticity. NANOG is a homeodomain-containing protein that binds specific DNA sequences to regulate gene expression programs required for maintenance of an undifferentiated state. As a key member of the core pluripotency network, NANOG functions alongside OCT4 and SOX2 to sustain embryonic stem cell identity and suppress differentiation pathways. NANOG Transcription Factor antibody is widely used in stem cell biology and developmental research to evaluate pluripotent cell populations and transcriptional regulation mechanisms.<br><br>NANOG expression is tightly controlled during early embryogenesis, becoming restricted to the inner cell mass of the blastocyst and later to epiblast cells. By activating genes associated with self-renewal and repressing lineage-specific transcriptional programs, NANOG helps maintain the balance between proliferation and differentiation. Its activity involves recruitment of chromatin-modifying complexes and interaction with other transcriptional regulators, enabling dynamic control of stem cell gene networks. Because of this central regulatory function, NANOG Transcription Factor antibody supports investigation of reprogramming efficiency, induced pluripotent stem cell generation, and developmental lineage commitment.<br><br>Beyond embryonic development, aberrant NANOG expression has been reported in multiple malignancies, where it has been associated with tumor-initiating capacity, therapeutic resistance, and stem-like phenotypes. In cancer research, NANOG Transcription Factor antibody is used to evaluate nuclear expression patterns and to study transcriptional programs linked to tumor progression and cellular dedifferentiation. NANOG protein localizes predominantly to the nucleus, consistent with its role as a transcriptional regulator, although cytoplasmic staining may also be observed depending on cell context and experimental conditions. Clone NANOG/9704 is designed to detect NANOG in research applications and enables investigation of pluripotency-associated signaling pathways and transcriptional regulation.

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