NTRK3 Antibody / Neurotrophic receptor tyrosine kinase 3 / TrkC, 100ug

NTRK3 antibody, also known as Neurotrophic receptor tyrosine kinase 3 antibody, recognizes a receptor tyrosine kinase commonly referred to as TrkC and Tropomyosin receptor kinase C. The NTRK3 gene encodes a transmembrane neurotrophin receptor that belongs to the Trk family of receptor tyrosine kinases, which also includes TrkA and TrkB. NTRK3 is primarily localized to the plasma membrane, where it functions as the high-affinity receptor for neurotrophin-3 (NT-3), and it can undergo ligand-induced internalization to endosomal compartments during signal transduction. Physiologically, NTRK3 plays a critical role in neuronal survival, differentiation, axonal growth, and synaptic plasticity, particularly during embryonic and postnatal development of the peripheral and central nervous systems.<br><br>Upon NT-3 binding, TrkC undergoes receptor dimerization and autophosphorylation within its intracellular kinase domain, activating downstream signaling cascades including the MAPK-ERK pathway, PI3K-AKT pathway, and PLC-gamma signaling. These pathways regulate gene expression programs involved in cell survival, neurite outgrowth, and cytoskeletal organization. Structurally, the receptor contains extracellular leucine-rich and immunoglobulin-like domains responsible for ligand binding, a single transmembrane region, and a cytoplasmic tyrosine kinase domain that mediates phosphorylation-dependent recruitment of adaptor proteins. The human NTRK3 gene is located on chromosome 15 and undergoes alternative splicing, generating isoforms with differences in signaling capacity and regulatory interactions.<br><br>In oncology, NTRK3 has gained substantial attention due to chromosomal rearrangements that generate oncogenic NTRK3 fusion proteins with constitutive kinase activity. Such fusions are detected in multiple tumor types and represent clinically actionable targets for TRK inhibitor therapies. In addition to gene fusions, altered expression of Neurotrophic receptor tyrosine kinase 3 has been studied in breast, thyroid, and other cancers, where context-dependent roles in tumor progression and differentiation have been reported. Clone NTRK3/8796 is designed to detect TrkC in research applications and is suitable for evaluating NTRK3 expression patterns in normal and neoplastic tissues. An NTRK3 antibody can be used to assess receptor distribution and relative expression in relevant experimental systems for life science research.

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