Zebrafish Psmc1 Antibody / Psmc1a / Psmc1b / 26S proteasome regulatory subunit 4, 100 ug

Psmc1 (Proteasome 26S subunit ATPase 1) is a crucial component of the 19S regulatory particle of the 26S proteasome complex, which is responsible for recognizing, unfolding, and translocating polyubiquitinated substrates into the 20S core for degradation. As an ATPase, Psmc1 belongs to the AAA family of ATPases and contributes mechanical energy required for substrate processing, making it essential for proteasome-mediated proteolysis.

In zebrafish, Psmc1 is the ortholog of the human PSMC1 gene. The zebrafish and human proteins show strong sequence and functional conservation, especially in the ATPase domain and other motifs critical for proteasome assembly and activity. This high degree of conservation supports the use of zebrafish as a model to study proteasomal function and its relevance to human disease.

Zebrafish Psmc1 may have multiple isoforms generated through alternative splicing. These isoforms can exhibit variation in domain composition or expression patterns and may play specific roles during different stages of development or under stress conditions. However, the canonical isoform is primarily responsible for forming the regulatory ATPase ring of the proteasome.

During zebrafish embryogenesis, Psmc1 is broadly expressed and particularly enriched in rapidly dividing and metabolically active tissues such as the central nervous system, developing musculature, and gastrointestinal organs. Its role in protein quality control is critical for proper cell cycle progression, apoptosis regulation, and differentiation.

In humans, mutations or dysregulation of PSMC1 have been associated with proteasome-related disorders and neurodevelopmental syndromes. Given its conserved function, zebrafish Psmc1 serves as an excellent model for exploring the molecular mechanisms of proteasome activity and its impact on developmental and pathological processes.