Zebrafish Pard3aa Antibody / Partitioning defective 3, 100 ug

Pard3aa (Partitioning defective 3 alpha) is a protein involved in regulating the polarization of cells during development and plays a critical role in establishing cellular asymmetry. It is a member of the Par protein family, which is essential for controlling the organization of the actin cytoskeleton, cell junctions, and cell signaling pathways. Pard3aa regulates processes like epithelial polarity, membrane trafficking, and cell-cell interactions, which are crucial for proper tissue development and function.

In zebrafish, Pard3aa is an ortholog of the human PARD3 gene. Both zebrafish and human Pard3aa share high sequence similarity and functional conservation, particularly in the regulation of cell polarity and cellular architecture. The similarities between the zebrafish and human versions of Pard3aa make zebrafish an excellent model for studying the molecular mechanisms of cell polarity, embryonic development, and tissue morphogenesis.

Pard3aa plays a vital role in the development of epithelial tissues, including the brain, gut, and heart, where it helps to establish and maintain apical-basal polarity. During embryogenesis, Pard3aa is involved in controlling embryo axis formation, cell migration, and the establishment of cellular asymmetry. It regulates the distribution of key proteins involved in junction formation and membrane trafficking, ensuring proper cell-cell adhesion and tissue integrity.

Given its role in developmental biology, cellular architecture, and tissue polarity, zebrafish Pard3aa serves as a useful model for studying fundamental processes like neural development, organogenesis, and cell polarity diseases. It is also an important protein for investigating human conditions related to developmental disorders, epithelial cancers, and neurodegenerative diseases that involve defects in cell polarity and cellular organization.