Zebrafish Glucocorticoid receptor Antibody / Gr / Nr3c1, 100 ug

Glucocorticoid receptor (Gr), also known as nuclear receptor subfamily three group C member one (Nr3c1), is a ligand activated transcription factor that mediates the effects of glucocorticoid hormones such as cortisol. In zebrafish, the glucocorticoid receptor plays a central role in regulating stress responses, metabolism, immune function, and early embryonic development.

The zebrafish glucocorticoid receptor is expressed in a wide range of tissues including the brain, liver, muscle, and developing endocrine organs. Upon binding to glucocorticoids, the receptor translocates to the nucleus where it binds specific DNA sequences and modulates the transcription of target genes involved in maintaining homeostasis under stress conditions. It also influences cell differentiation, energy balance, and the inflammatory response.

In zebrafish embryos, activation or disruption of glucocorticoid signaling affects key developmental processes such as axis formation, organ maturation, and behavioral programming. Because zebrafish produce cortisol as their primary glucocorticoid, they serve as a powerful model for investigating hormone signaling and endocrine regulation in vertebrates.

The glucocorticoid receptor in zebrafish is widely used in research on stress physiology, neuroendocrine development, immune modulation, and environmental toxicology. It is also a valuable target in studies examining the effects of synthetic glucocorticoids and endocrine disrupting compounds.