Zebrafish Atoh7 Antibody / Lakritz, 100 ug

Atonal homolog 7 (Atoh7), also known as Lakritz, is a basic helix-loop-helix (bHLH) transcription factor that plays an essential role in retinal neurogenesis, particularly in the specification of retinal ganglion cells (RGCs). In zebrafish (Danio rerio), Atoh7 is critical for the early stages of eye development, where it governs the differentiation of progenitor cells into RGCs-the first retinal neurons to extend axons to the brain.

During zebrafish embryogenesis, atoh7 is expressed in retinal progenitor cells, and its activity initiates the genetic cascade required for RGC formation and optic nerve development. Mutations in atoh7, such as in the lakritz mutant, result in the complete absence of RGCs and a failure to form the optic nerve, making it a key model for studying retinal development, axonal pathfinding, and neuronal lineage commitment.

Given its conserved function across vertebrates, zebrafish Atoh7 is widely used in research on eye development, stem cell differentiation, and regenerative medicine targeting visual system repair. It also serves as a molecular marker for early neurogenesis in the retina.