Zebrafish Alcama Antibody / Neurolin, 100 ug

Activated leukocyte cell adhesion molecule a (Alcama), also known as Neurolin, is a member of the immunoglobulin superfamily of cell adhesion molecules. In zebrafish (Danio rerio), Alcama plays a vital role in axon guidance, cell-cell adhesion, and tissue morphogenesis, particularly during the development of the nervous system, vasculature, and hematopoietic system.

Alcama is prominently expressed in developing neurons, where it mediates axon fasciculation and growth cone navigation, facilitating the formation of organized neuronal tracts. In addition to its role in neurodevelopment, zebrafish Alcama is expressed in vascular endothelial cells and hematopoietic stem and progenitor cells (HSPCs), where it contributes to vasculogenesis, vascular remodeling, and stem cell niche formation.

Due to its conserved structure and multifunctional roles, zebrafish Alcama is a valuable model for studying cell adhesion dynamics, nervous system wiring, hematopoietic development, and angiogenesis. It is also used in research related to immune cell migration, axon pathfinding disorders, and regenerative medicine.