Zebrafish Tfap2a Antibody / Ap2 alpha, 100 ug

Transcription factor AP-2 alpha (Tfap2a) is a DNA-binding transcription factor that plays a critical role in embryonic development by regulating genes involved in cell fate determination, proliferation, and differentiation. In zebrafish (Danio rerio), Tfap2a is essential for the proper development of the neural crest, craniofacial structures, epidermis, and parts of the central nervous system.

Tfap2a is expressed early in development, particularly in the neural plate border and migrating neural crest cells. It functions by activating or repressing target genes involved in ectodermal and neural crest lineage specification. Loss-of-function studies in zebrafish have demonstrated that tfap2a is required for cranial neural crest formation, melanocyte differentiation, and proper facial cartilage patterning.

Given its high degree of conservation and developmental importance, zebrafish Tfap2a is widely used as a model to study craniofacial anomalies, neural crest biology, and transcriptional regulation during vertebrate embryogenesis. It is also a valuable marker for identifying early ectodermal and neural crest derivatives.