Cd163 Antibody, 100 ug

Cd163 is a type I transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. It is highly expressed on cells of the monocyte/macrophage lineage, where it functions as a hemoglobin-haptoglobin complex receptor. By mediating clearance of hemoglobin from sites of tissue damage or intravascular hemolysis, Cd163 plays a central role in protecting tissues from oxidative stress and inflammation. A Cd163 antibody is frequently used to study macrophage biology, immune regulation, and tissue remodeling in both mouse and rat models.

Cd163 expression is strongly associated with alternatively activated (M2) macrophages, which are involved in anti-inflammatory processes, tissue repair, and immunosuppression. This makes Cd163 a valuable marker for identifying macrophage polarization states. Employing a Cd163 antibody allows researchers to investigate the dynamics of macrophage activation in response to injury, infection, or disease progression.

Beyond its role in hemoglobin clearance, Cd163 has broader immunomodulatory functions. Engagement of Cd163 can trigger anti-inflammatory signaling cascades and promote the release of heme oxygenase-1, further contributing to cytoprotection. Dysregulated Cd163 expression has been implicated in conditions such as sepsis, atherosclerosis, and chronic inflammatory diseases. In cancer, Cd163-positive macrophages are often linked to tumor-associated macrophages (TAMs), which can support tumor growth and immune evasion. A Cd163 antibody is therefore a powerful tool in both basic immunology and translational research.

NSJ Bioreagents provides a high-quality Cd163 antibody validated for use in western blot, immunohistochemistry, and flow cytometry. Choosing a Cd163 antibody from NSJ Bioreagents ensures reliable performance and reproducibility in studies of macrophage biology, immune responses, and inflammation in rodent models.