SPRED2 Antibody / Sprouty-related EVH1 domain-containing protein 2, 100 ug

SPRED2 (Sprouty-related EVH1 domain-containing protein 2) is a member of the SPRED protein family, which negatively regulates receptor tyrosine kinase (RTK) signaling pathways. By interacting with components of the Ras/MAPK cascade, SPRED2 suppresses excessive ERK activation, thereby controlling cellular processes such as proliferation, differentiation, and migration. Researchers frequently use a SPRED2 antibody to investigate signaling dynamics and the molecular mechanisms of growth factor regulation.

SPRED2 contains an N-terminal Ena/VASP homology 1 (EVH1) domain, a central c-Kit binding domain, and a C-terminal Sprouty-related cysteine-rich domain. These structural motifs allow SPRED2 to localize to the plasma membrane and recruit signaling proteins, where it inhibits Ras and Raf activation. Employing a SPRED2 antibody allows scientists to study how this protein maintains signaling balance across a variety of cell types.

Altered expression of SPRED2 has been linked to human disease. Loss or reduction of SPRED2 function has been associated with enhanced MAPK pathway activity, which may contribute to oncogenesis and abnormal tissue growth. Additionally, SPRED2 is studied in the context of immune regulation and inflammation, where dysregulated signaling can lead to pathological outcomes. Using a SPRED2 antibody supports research into these processes and offers insight into therapeutic strategies aimed at modulating Ras/MAPK signaling.

NSJ Bioreagents offers a high-quality SPRED2 antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a SPRED2 antibody from NSJ Bioreagents ensures reliable detection and reproducible performance in studies of signal transduction, cell regulation, and disease biology.