CEACAM5 Antibody / CEA, 100 ug

CEA (Carcinoembryonic antigen), also called CEACAM5, is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEACAM5 stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEACAM5 is a glycosyl phosphatidyl inositol(GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. CEACAM5 and related genes make up the CEA family belonging to the immunoglobulin superfamily. In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed.