TAS2R10 Antibody / Taste receptor type 2 member 10, 100 ug

TAS2R10 antibody detects Taste receptor type 2 member 10, a G protein-coupled receptor (GPCR) encoded by the TAS2R10 gene located on chromosome 12p13.2. TAS2R10 belongs to the bitter taste receptor family and is primarily responsible for detecting bitter compounds in the oral cavity, but it is also expressed in extraoral tissues including airway epithelium, gastrointestinal tract, and immune cells. These broader expression patterns indicate additional roles in innate immunity, smooth muscle regulation, and metabolic signaling.

TAS2R10 is a seven-transmembrane receptor that binds structurally diverse bitter ligands and activates intracellular signaling via gustducin or Galpha subunits. Ligand binding leads to activation of phospholipase C beta 2 (PLCB2), production of inositol trisphosphate (IP3), and release of calcium from intracellular stores. This signaling cascade triggers neuronal depolarization and perception of bitterness. In non-gustatory tissues, TAS2R10 signaling influences ciliary motility, bronchodilation, and antimicrobial peptide secretion. Known ligands include denatonium benzoate, quinine, and brucine.

Structurally, TAS2R10 contains seven alpha-helical transmembrane domains, three extracellular loops for ligand recognition, and a cytoplasmic tail that interacts with G proteins. It belongs to the class A rhodopsin-like GPCR family, which mediates diverse sensory and hormonal signals. TAS2R10 is part of the taste receptor type 2 (T2R) subfamily, which includes approximately 25 functional bitter receptors in humans. Co-localization studies show TAS2R10 present in taste buds, bronchial cilia, and intestinal enteroendocrine cells, reflecting its multifunctional physiological roles.

Functionally, TAS2R10 contributes to gustatory perception as well as airway and gastrointestinal physiology. In airway smooth muscle, activation of TAS2R10 induces relaxation through localized calcium signaling, helping to counteract bronchoconstriction. In the gastrointestinal tract, it modulates hormone release and gut motility. TAS2R10 also contributes to innate immune defense by detecting bacterial metabolites and triggering ciliary clearance mechanisms in respiratory epithelium. During development, TAS2R10 expression appears after taste bud differentiation, coinciding with sensory nerve maturation.

Dysregulation or genetic variation in TAS2R10 may influence taste perception, dietary preferences, and susceptibility to airway diseases. Polymorphisms affecting receptor sensitivity are linked to interindividual differences in bitter compound detection. Pathway associations include GPCR signaling, calcium mobilization, and innate immune responses. In pharmacological research, TAS2R10 is being studied for its potential in bronchodilator and metabolic regulation therapies.

The TAS2R10 antibody from NSJ Bioreagents is a useful reagent for studying GPCR-mediated signaling, sensory transduction, and extraoral taste receptor functions.