ADORA2A Antibody / Adenosine receptor A2A, 100 ug

ADORA2A antibody recognizes Adenosine receptor A2A, a G protein-coupled receptor (GPCR) that mediates adenosine signaling to regulate neurotransmission, vascular tone, and immune responses. The ADORA2A gene, located on chromosome 22q11.23, encodes a seven-transmembrane domain receptor coupled to Gs proteins that stimulate cyclic AMP (cAMP) production upon adenosine binding. This receptor is highly expressed in the central nervous system, particularly in the striatum, as well as in immune cells, endothelial cells, and platelets.

Structurally, ADORA2A consists of an extracellular ligand-binding pocket for adenosine and intracellular domains that interact with G proteins and regulatory kinases. The receptor plays a critical role in modulating dopaminergic neurotransmission, motor control, and sleep regulation. Pharmacologically, ADORA2A is a therapeutic target for Parkinson’s disease and psychiatric disorders due to its antagonistic interaction with dopamine D2 receptors. In the cardiovascular system, ADORA2A activation causes vasodilation and platelet inhibition, contributing to tissue perfusion and anti-thrombotic effects.

ADORA2A signaling also exerts immunomodulatory functions by suppressing pro-inflammatory cytokine production and promoting regulatory T cell activity. Dysregulation of this receptor is linked to neurodegenerative diseases, ischemia, and autoimmune conditions. Overexpression of ADORA2A in certain tumors supports immunosuppressive microenvironments by inhibiting T-cell activation, making it an emerging target for cancer immunotherapy. Structural and mutational analyses have revealed key residues responsible for ligand specificity and receptor desensitization through phosphorylation and arrestin binding.

Immunohistochemical staining using ADORA2A antibody shows membrane and cytoplasmic localization in neurons, endothelial cells, and lymphocytes. ADORA2A antibody from NSJ Bioreagents provides a powerful tool for studying adenosine-mediated signaling, neuroprotection, cardiovascular regulation, and tumor immunology.