PARVG Antibody / Gamma Parvin, 100 ug

PARVG antibody detects Gamma-parvin, a cytoskeletal adaptor protein that links integrins to actin filaments and regulates cell adhesion, motility, and signaling. The UniProt recommended name is Gamma-parvin (PARVG). This protein is a member of the parvin family of actin-binding proteins associated with focal adhesions and integrin-linked kinase (ILK) complexes.

Functionally, PARVG antibody identifies a 372-amino-acid cytoplasmic protein containing two calponin-homology (CH) domains that mediate actin binding and integrin interaction. PARVG participates in integrin-mediated adhesion signaling, influencing cell spreading, migration, and cytoskeletal dynamics. It contributes to mechanotransduction pathways in endothelial and immune cells.

The PARVG gene is located on chromosome 22q13.31 and is expressed in leukocytes, vascular smooth muscle cells, and skeletal muscle. PARVG regulates integrin activation and focal adhesion turnover, playing a key role in immune cell motility and vascular integrity.

Pathologically, altered PARVG expression has been linked to cancer cell migration, vascular remodeling, and inflammatory responses. Dysregulation of PARVG contributes to defective adhesion signaling and cytoskeletal organization. Research using PARVG antibody supports studies in integrin signaling, cytoskeletal remodeling, and vascular biology.

PARVG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect cytoskeletal and adhesion-associated proteins. NSJ Bioreagents provides PARVG antibody reagents optimized for research in adhesion signaling, actin dynamics, and immune cell motility.

Structurally, Gamma-parvin contains CH1 and CH2 domains that facilitate actin binding and ILK-PINCH complex formation. This antibody aids in analyzing PARVG's function in integrin-linked cytoskeletal networks and adhesion regulation.