CREB3 Antibody / Cyclic AMP-responsive element-binding protein 3, 100 ug

CREB3 antibody detects Cyclic AMP-responsive element-binding protein 3, a transcription factor involved in the unfolded protein response and endoplasmic reticulum (ER) stress regulation. The UniProt recommended name is Cyclic AMP-responsive element-binding protein 3 (CREB3). This ER membrane-bound transcription factor controls gene expression related to protein folding, trafficking, and secretion.

Functionally, CREB3 antibody identifies a 371-amino-acid protein anchored in the ER membrane with a cytoplasmic basic leucine zipper (bZIP) domain. Upon ER stress, the N-terminal transcriptional domain of CREB3 is cleaved and translocated to the nucleus, where it activates target genes involved in secretion and Golgi maintenance. CREB3 also regulates acute phase response genes and collagen biosynthesis.

The CREB3 gene is located on chromosome 9p13.3 and is highly expressed in secretory tissues such as liver, pancreas, and intestine. It plays a central role in adapting to increased secretory load and maintaining ER homeostasis under stress conditions.

Pathologically, dysregulation of CREB3 contributes to metabolic disorders, neurodegeneration, and cancer progression by disturbing ER stress response pathways. Overexpression can enhance tumor invasion by modulating extracellular matrix and stress-related signaling genes. Research using CREB3 antibody supports studies in transcriptional regulation, ER stress, and secretory pathway biology.

CREB3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors and stress response regulators. NSJ Bioreagents provides CREB3 antibody reagents optimized for research in cellular homeostasis, transcription, and disease adaptation.

Structurally, Cyclic AMP-responsive element-binding protein 3 contains a bZIP domain for DNA binding and dimerization, along with a luminal stress-sensing region. This antibody enables investigation of CREB3's role in ER stress signaling and transcriptional control.