HAUS6 Antibody / HAUS augmin-like complex subunit 6 / FAM29A, 100 ug

HAUS6 antibody detects HAUS augmin-like complex subunit 6, also known as FAM29A, a microtubule-associated protein essential for mitotic spindle assembly and centrosome organization. The UniProt recommended name is HAUS augmin-like complex subunit 6 (HAUS6). This protein is a core component of the eight-subunit human augmin (HAUS) complex, which promotes the generation of branched microtubules during mitosis.

Functionally, HAUS6 antibody identifies a 949-amino-acid cytoplasmic protein that localizes to spindle microtubules and centrosomes. HAUS6 stabilizes kinetochore fibers and recruits gamma-tubulin ring complexes (gamma-TuRCs) to existing microtubules, amplifying spindle microtubule density. This process is critical for accurate chromosome alignment and segregation during cell division.

The HAUS6 gene is located on chromosome 15q24.2 and is expressed in proliferative tissues, including bone marrow, testis, and embryonic cells. Its activity supports mitotic fidelity and genome stability, coordinating spindle organization and kinetochore function.

Pathologically, dysregulation of HAUS6 impairs spindle formation, resulting in chromosomal instability and aneuploidy, features often associated with tumorigenesis. Overexpression of HAUS6 has been linked to cancer progression through enhanced mitotic activity and centrosome amplification. Research using HAUS6 antibody supports studies in mitosis, microtubule nucleation, and cell cycle control.

HAUS6 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect spindle assembly proteins. NSJ Bioreagents provides HAUS6 antibody reagents optimized for studies in cell division, cytoskeletal organization, and cancer biology.

Structurally, HAUS augmin-like complex subunit 6 contains coiled-coil domains that mediate assembly of the augmin complex and interaction with other HAUS components such as HAUS1-HAUS8. This antibody enables analysis of HAUS6's role in spindle microtubule branching and mitotic regulation.