EURL Antibody / Expressed in undifferentiated retina and lens / C21orf91, 100 ug

EURL antibody detects C21orf91 protein, also known as EURL (expressed in undifferentiated retina and lens), a cytoplasmic regulator of neurogenesis and neuronal differentiation. The UniProt recommended name is C21orf91 protein (EURL). This protein contributes to neurodevelopment by modulating the balance between neural progenitor proliferation and differentiation.

Functionally, EURL antibody identifies a 250-amino-acid cytoplasmic protein that interacts with components of the microtubule and actin cytoskeleton to influence cell shape and division. EURL expression is enriched in neural precursor cells, where it controls neuronal lineage specification and cortical development. It also supports early lens and retinal formation during embryogenesis.

The EURL gene is located on chromosome 21q22.12, within the Down syndrome critical region. Its expression in the developing brain suggests a role in cortical layering and synaptic maturation. EURL may also contribute to dosage-sensitive developmental pathways affected by trisomy 21.

Pathologically, altered EURL expression has been associated with neurodevelopmental delay and Down syndrome-related brain abnormalities. Dysregulation affects neuronal migration and axon guidance, leading to impaired neural circuit formation. Research using EURL antibody supports studies in brain development, neurogenetics, and cytoskeletal dynamics.

EURL antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neural differentiation markers. NSJ Bioreagents provides EURL antibody reagents optimized for neurobiology, developmental, and genetic research.

Structurally, C21orf91 protein contains conserved helical motifs that mediate cytoskeletal binding and spatial organization within developing neurons. This antibody enables analysis of EURL's role in neuronal specification and brain morphogenesis.