TCTN1 Antibody / Tectonic 1, 100 ug

TCTN1 antibody detects Tectonic-1, a membrane-associated protein essential for ciliogenesis and Hedgehog signaling. The UniProt recommended name is Tectonic-1 (TCTN1). This protein localizes to the ciliary transition zone, where it participates in the formation and maintenance of the primary cilium, a sensory organelle crucial for signal transduction during embryonic development and tissue patterning.

Functionally, TCTN1 antibody identifies a 765-amino-acid protein that interacts with other tectonic complex components such as TCTN2, TCTN3, and MKS1. TCTN1 regulates protein trafficking into the cilium and ensures the proper localization of signaling receptors, including those of the Hedgehog pathway. It is indispensable for normal morphogenesis and neural tube patterning.

The TCTN1 gene is located on chromosome 12q24.11 and is expressed in ciliated cells throughout various tissues, including brain, kidney, and retina. Its activity maintains ciliary structure and mediates signal coordination during development and organogenesis.

Pathologically, mutations in TCTN1 lead to ciliopathies such as Joubert and Meckel-Gruber syndromes, which are characterized by developmental defects in the brain, kidneys, and eyes. Dysfunction of TCTN1 disrupts ciliary signaling, resulting in structural malformations and impaired embryonic patterning. Research using TCTN1 antibody supports studies in ciliary biology, developmental signaling, and ciliopathy mechanisms.

TCTN1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect ciliary transition zone proteins. NSJ Bioreagents provides TCTN1 antibody reagents optimized for developmental biology, signal transduction, and structural cell biology research.

Structurally, Tectonic-1 contains multiple coiled-coil regions and a C-terminal transmembrane domain that anchor it to the ciliary membrane. This antibody enables investigation of TCTN1's function in ciliogenesis and Hedgehog pathway regulation.