MEPCE Antibody / 7SK snRNA methylphosphate capping enzyme, 100 ug

MEPCE antibody detects 7SK snRNA methylphosphate capping enzyme, a nuclear RNA methyltransferase that stabilizes 7SK small nuclear RNA and regulates transcription elongation. The UniProt recommended name is 7SK snRNA methylphosphate capping enzyme (MEPCE). This enzyme catalyzes the methylation of the 5? gamma-phosphate of 7SK snRNA, forming a protective cap structure critical for RNA stability.

Functionally, MEPCE antibody identifies a 689-amino-acid enzyme that binds to 7SK snRNA within the 7SK ribonucleoprotein complex. MEPCE cooperates with LARP7 and HEXIM1 to maintain repression of positive transcription elongation factor b (P-TEFb), thereby controlling RNA polymerase II elongation and global transcriptional output. It serves as a key regulator of gene expression homeostasis.

The MEPCE gene is located on chromosome 7q22.3 and is ubiquitously expressed, with enrichment in transcriptionally active tissues such as brain, liver, and gonads. MEPCE function is essential for normal development and maintenance of chromatin transcription dynamics.

Pathologically, mutations or reduced expression of MEPCE cause neurodevelopmental disorders characterized by intellectual disability and seizures. Disruption of 7SK complex stability leads to uncontrolled transcription elongation and altered gene expression. Research using MEPCE antibody supports studies in RNA biology, transcription regulation, and neurological disease mechanisms.

MEPCE antibody is validated for western blotting, immunoprecipitation, and immunofluorescence to detect RNA methyltransferases and transcriptional regulators. NSJ Bioreagents provides MEPCE antibody reagents optimized for research in RNA processing, chromatin regulation, and transcription control.

Structurally, 7SK snRNA methylphosphate capping enzyme contains a conserved methyltransferase domain that binds S-adenosylmethionine and the 7SK RNA substrate. This antibody facilitates investigation of MEPCE's enzymatic role in transcriptional repression and RNA stability.