SLFN14 Antibody / Schlafen family member 14, 100 ug

SLFN14 antibody detects Schlafen family member 14, an endoribonuclease that regulates platelet formation, immune function, and mRNA decay. The UniProt recommended name is Schlafen family member 14 (SLFN14). This protein belongs to the Schlafen family, which modulates cell proliferation, differentiation, and antiviral defense through RNA processing and translation control.

Functionally, SLFN14 antibody identifies a 505-amino-acid cytoplasmic enzyme that cleaves ribosomal and messenger RNA, regulating protein synthesis and megakaryocyte maturation. SLFN14 is expressed in platelets and hematopoietic cells, where it promotes proper thrombocyte formation and prevents excessive RNA accumulation. It also contributes to innate immune defense by degrading viral RNA.

The SLFN14 gene is located on chromosome 17q12 and is primarily expressed in bone marrow, platelets, and immune cells. SLFN14 activity links RNA metabolism with hematopoiesis and antiviral immunity. Its function depends on ATP-binding and nuclease domains that enable targeted RNA degradation.

Pathologically, mutations in SLFN14 cause inherited thrombocytopenia, a bleeding disorder characterized by reduced platelet count and function. These mutations impair endoribonuclease activity, leading to defective megakaryocyte development. Research using SLFN14 antibody supports studies in hematopoiesis, RNA biology, and immune regulation.

SLFN14 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect RNA-processing enzymes. NSJ Bioreagents provides SLFN14 antibody reagents optimized for studies in hematology, molecular biology, and innate immunity.

Structurally, Schlafen family member 14 features conserved Schlafen core and nuclease domains that coordinate RNA cleavage and nucleotide binding. This antibody enables exploration of SLFN14's role in platelet formation and RNA turnover.