FBXO7 Antibody / F-box only protein 7, 100 ug

FBXO7 antibody detects F-box only protein 7, an E3 ubiquitin ligase component that regulates protein degradation, cell cycle progression, and mitochondrial quality control. The UniProt recommended name is F-box only protein 7 (FBXO7). This protein belongs to the F-box family, which mediates substrate recognition within SCF (SKP1-CUL1-F-box) ubiquitin ligase complexes, promoting selective proteasomal degradation of target proteins.

Functionally, FBXO7 antibody identifies a 522-amino-acid cytoplasmic and nuclear protein containing an F-box domain for SCF complex binding and a proline-rich region that mediates protein-protein interactions. FBXO7 participates in cell cycle regulation by targeting cell cycle inhibitors for ubiquitination. It also plays a role in mitophagy by interacting with PINK1 and Parkin to promote the clearance of damaged mitochondria, maintaining neuronal and muscular health.

The FBXO7 gene is located on chromosome 22q12.3 and is broadly expressed, with high levels in brain, skeletal muscle, and lymphoid tissues. Its cellular distribution reflects multifunctional roles in ubiquitin-mediated proteolysis, cytoskeletal organization, and signal transduction.

Pathologically, mutations in FBXO7 are associated with Parkinsonian-pyramidal syndrome (PARK15), a neurodegenerative disorder combining parkinsonism with upper motor neuron dysfunction. Loss of FBXO7 disrupts mitophagy, leading to mitochondrial dysfunction and neurodegeneration. Research using FBXO7 antibody supports studies in protein degradation, neurobiology, and mitochondrial homeostasis.

FBXO7 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect F-box proteins and ubiquitination regulators. NSJ Bioreagents provides FBXO7 antibody reagents optimized for studies in proteostasis, neurodegeneration, and cell cycle control.

Structurally, F-box only protein 7 contains an F-box domain for SKP1 binding, coiled-coil regions for dimerization, and a ubiquitin-like domain that facilitates substrate recruitment. This antibody enables detailed characterization of FBXO7's function in E3 ligase activity and mitochondrial quality control.